Extraction Process, Structural Characterization, and Digestive Properties of Type 3 Resistant Starch (RS3) from Angelica dahurica, and Its Impact on Gut Health in Obese Mice

Introduction Obesity and its related metabolic disorders are global health concerns, largely linked to diet and gut microbial imbalance. Functional food ingredients such as resistant starches (RS) are being explored as potential nutritional interventions. Angelica dahurica , a traditional medicinal plant, is a promising source of starch that can be processed into type 3 resistant starch (RS3). RS3 is formed through retrogradation of gelatinized starch and has shown significant health-promoting effects, especially in gut health regulation and obesity management. Meaning of RS3 Type 3 resistant starch (RS3) refers to retrograded starch molecules that resist digestion in the small intestine. Instead of being broken down into glucose, RS3 passes to the large intestine where it undergoes microbial fermentation, producing short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate. These metabolites improve gut health , regulate immunity, and support metabolic balance. Adva...